Research project Targeting neuron-to-glioma synapses in glioblastoma: New therapeutic avenues blocking malignant gene regulatory networks
Glioblastoma is an aggressive brain cancer that is driven in part by signals from neurons. We aim to uncover and disrupt the gene regulatory networks that enable communication between neurons and tumour cells. By combining advanced genomic technologies, single-cell analysis and targeted protein degradation, we seek new strategies to block tumour progression by disrupting neuron-tumour connections, and make glioblastoma more treatable.
