Talare: Shahriar Mobashery, Notre Damme University, USA
Värd: Felipe Cava, Institutionen för molekylärbiologi, MIMS
Föreläsningen är på engelska
Members of Enterobacteriaceae and Pseudomonas aeruginosa have the ability to sense damage inflicted to their cell wall. The process involves chemical signaling, which will be a subject of my presentation.
A primary mechanism for this sensing and signalling involves the events of cell-wall recycling. The cell wall is degraded for recycling and then the cell wall is synthesized de novo for the repair function. The recycling events get initiated by the functions of a family of 11 lytic transglycosylases in P. aeruginosa, which generate the signalling factors that influence transcriptional events in the cytoplasm. The mechanisms of these processes and those of the early cytoplasmic steps of recycling have been the subject of study in my lab, which I will disclose in my presentation.